Microchip Technology

ATMEGA2560-16AU - 8-bit AVR MCU 256KB Flash 16MHz | Microchip

MPN: ATMEGA2560-16AU βœ“ Active
In Stock Ships in 1-3 business days
4.5 V to 5.5 V (at 16 MHz) Vdss 100-TQFP (14x14 mm) Package 16 MHz Speed FLASH (ISP) Memory
From $8.87 USD / Unit
MOQ: 1 |
Price updated: 2026-09-16
Volume Pricing
Qty Unit Price Extended
1 $11.21 $11.21
10 $10.65 $106.50
100 $9.98 $998.00
500 $9.42 $4,710.00
1,000 $8.87 $8,870.00
ℹ️ All prices are in USD

ATMEGA2560-16AU Overview

The Microchip Technology ATMEGA2560-16AU is a high-performance, low-power 8-bit AVR RISC microcontroller with 256 KB ISP Flash, 8 KB SRAM, 4 KB EEPROM, 86 general-purpose I/O lines, and a maximum clock frequency of 16 MHz, housed in a 100-pin TQFP (14x14 mm) package.

A microcontroller unit (MCU) is a single integrated circuit that combines a processor core, memory, and programmable peripherals into one chip, forming the lowest tier of the embedded computing hierarchy (MCU -> embedded processor -> system-on-chip -> computing system). The ATmega2560 belongs to the AVR family of enhanced RISC microcontrollers, executing most instructions in a single clock cycle to achieve throughput approaching 1 MIPS per MHz, allowing designers to optimize power consumption versus processing speed.

Key features include 256 KB of in-system programmable Flash with a separate boot sector supporting In-Application Programming, 4 KB EEPROM for non-volatile parameter storage, 8 KB internal SRAM, and 86 GPIO lines with internal pull-ups. The peripheral set comprises six flexible timer/counters with compare modes, four 8-bit PWM channels, six/two 16-bit PWM channels, an 8-channel 10-bit ADC, four USARTs, SPI, TWI (I2C), and a JTAG interface for on-chip debugging and boundary scan.

The AVR core uses a Harvard architecture with 32 general-purpose working registers directly connected to the ALU, so two independent registers can be accessed in one instruction executed in one cycle. This RISC structure delivers code efficiency and deterministic execution suited to real-time control tasks, while the rich peripheral bank offloads timing-critical functions from software.

Typical applications include the Arduino Mega 2560 development platform, industrial automation controllers, robotics and motor control systems, and instrumentation requiring many I/O channels and multiple serial links. Four hardware USARTs and the 86 I/O lines make it especially popular for boards that must drive shields, displays, and sensors simultaneously.

When designing with the ATMEGA2560-16AU, remember it is rated for 4.5V to 5.5V operation at 16 MHz; lower-speed grades (the V variant) run at reduced voltage, so check supply rail compatibility before substituting. Provide 100 nF decoupling on each VCC pin pair and route the analog AVCC supply cleanly for best ADC accuracy.

This page synthesizes distributor pricing, drop-in alternatives, pinout guidance, and practical design notes not found in the manufacturer datasheet.

Drop-in alternatives for ATMEGA2560-16AU β€” same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with ATMEGA2560-16AU (same form factor and footprint) β€” differing in Package, ADC Channels, Instructions, Supply Voltage Range, Timers/Counters.

Microchip Technology
Package: 100-TQFP (14 x 14 mm, 1.0 mm height)
ADC Channels: 16-channel, 10-bit
Instructions: 133 instructions, most single-cycle
Compare with ATMEGA2560-16AU β†’
Microchip Technology
Package: 100-pin TQFP
Instructions: 131, most single-cycle
Supply Voltage Range: 1.8 V to 5.5 V
Compare with ATMEGA2560-16AU β†’

Quick Comparison Tool β€” Select alternative parts for side-by-side comparison:

ATMEGA1280-16AU

βœ… Drop-In
πŸ“¦ 100-TQFP (14x14 mm)
Flash 128 KB vs 256 KB (-50%), same SRAM/peripherals, pin-to-pin

πŸ“‹ Reference alternative (not in catalog)

ATMEGA640-16AU

βœ… Drop-In
πŸ“¦ 100-TQFP (14x14 mm)
Flash 64 KB vs 256 KB (-75%), same core/peripherals/I-O count

πŸ“‹ Reference alternative (not in catalog)

ATMEGA2560V-8AU

βœ… Drop-In
Microchip Technology
πŸ“¦ 100-TQFP (14x14 mm)
8-bit AVR RISC Β· 256 KB FLASH Β· 8 KB Β· 4 KB Β· 86 pins Β· 1.8 V to 5.5 V Β· 8 MHz Β· 16-channel, 10-bit

βœ“ In Stock

$11.3 / Unit

View Datasheet β†’

ATMEGA2560-16AU Maximum Ratings & Electrical Characteristics

Core Architecture 8-bit AVR RISC
Core Size 8-bit
Max Clock Frequency 16 MHz
Program Memory Type FLASH (ISP)
Flash Memory Size 256 KB (128K x 16)
SRAM Size 8 KB
EEPROM Size 4 KB
Number of I/O Lines 86
Working Registers 32 general purpose
Supply Voltage (VCC) 4.5 V to 5.5 V (at 16 MHz)
ADC Resolution 10 bit
ADC Channels 8 (16 with ADC mux on PK port)
Number of USARTs 4
Timers/Counters 6 (flexible, with compare and PWM modes)
Interface Types SPI, TWI (I2C), JTAG, USART
Package 100-TQFP (14x14 mm)
Mounting Type Surface Mount
MIPS Up to 16 MIPS (approx. 1 MIPS per MHz)

ATMEGA2560-16AU 100-tqfp (14x14 mm) Pin Configuration Guide

Pin configuration for ATMEGA2560-16AU (100-tqfp (14x14 mm) package). This digital IC includes GPIO, communication interfaces (UART, SPI, I2C), and power pins. Refer to the manufacturer datasheet for alternate pin functions and configuration options. Essential for embedded system design and PCB layout.

100-tqfp (14x14 mm) package pinout diagram for ATMEGA2560-16AU

No detailed pinout data available for ATMEGA2560-16AU.

Refer to the datasheet for full pin configuration.

Typical Applications

ATMEGA2560-16AU is suitable for 6 applications: Arduino Mega 2560 Platform, Industrial Automation Control, Robotics and Motor Control, Instrumentation and Data Logging, Building Automation and Smart Home Hubs, Prototyping and Education.

🧩

Arduino Mega 2560 Platform

The ATMEGA2560-16AU is the official core processor of the Arduino Mega 2560 and its R3 revisions. Its 256 KB Flash hosts the Arduino bootloader plus large user sketches, while 86 GPIO lines map directly to the Mega's 54 digital and 16 analog headers, allowing multiple stacked shields to operate simultaneously. Four hardware USARTs serve USB-serial bridging and external serial devices without software emulation overhead. Its 16 MHz clock yields roughly 16 MIPS, adequate for typical Arduino workloads, and its 5V logic matches the vast ecosystem of legacy Arduino shields that never migrated to 3.3V platforms.

🏭

Industrial Automation Control

In factory automation panels, the ATMEGA2560-16AU's 86 I/O lines replace external port expanders, reducing BOM cost and failure points in relay- and sensor-heavy control logic. The six timers generate precise PWM for actuators and provide input capture for sensor pulse timing, while the four USARTs interface Modbus RTU slaves, HMI panels, and barcode readers concurrently. Its 5V noise margin suits electrically harsh cabinets better than 3.3V MCUs, and the 10-bit ADC handles analog transducer inputs with adequate resolution for monitoring. The JTAG interface supports on-chip debugging during commissioning of machine-control firmware.

🏭

Robotics and Motor Control

Robot controllers benefit from the ATMEGA2560-16AU's multiple 16-bit timers, which drive up to dozens of servo channels with hardware-scheduled pulses, freeing CPU cycles for navigation algorithms. Sixteen analog input channels monitor battery voltage, current sense resistors, and potentiometer feedback, while four USARTs connect motor drivers, IMUs, and telemetry radios in parallel. The 8 KB SRAM accommodates kinematics buffers and sensor fusion state that overflow smaller AVRs. The Mega footprint's popularity in robotics (line-followers, hexapods, 3D printer mainboards) means extensive community code and shield hardware already target this exact MCU.

πŸ”§

Instrumentation and Data Logging

Test and measurement fixtures use the ATMEGA2560-16AU as a sequencer and data aggregator: its 10-bit ADC with 16 muxed channels samples up to 16 sensor points, EEPROM (4 KB) stores calibration constants that survive power cycles, and 256 KB Flash holds firmware plus buffered lookup tables. Four USARTs stream results to a host PC, a thermal printer, and a display controller simultaneously. The TWI (I2C) bus adds external EEPROM or RTC expansion. Its deterministic single-cycle RISC execution gives repeatable sample timing, which matters for logging intervals and PWM stimulus generation in bench fixtures.

🏠

Building Automation and Smart Home Hubs

Custom home-automation controllers employ the ATMEGA2560-16AU where many wired points are needed: 86 GPIO lines handle zone switches, relays, and LED indicators directly, while the TWI bus addresses environmental sensor clusters. The 5V supply tolerance simplifies integration with legacy alarm-panel signaling that does not conform to 3.3V logic levels. Its 256 KB Flash supports substantial protocol stacks such as MQTT-over-serial or X10 implementations with room for OTA-style bootloaders, and the 8 KB SRAM holds multiple socket buffers. Four USARTs allow simultaneous RS-485, RS-232, and wireless module interfaces in one node.

πŸ”§

Prototyping and Education

Engineering education and rapid prototyping platforms standardize on the ATMEGA2560-16AU because the Arduino Mega ecosystem provides mature toolchains, bootloaders, and libraries that remove initial tooling friction. Students wire directly to the 5V-tolerant 86 I/O lines without level shifters, and the generous Flash (256 KB) means complex course projects never hit memory limits. In professional prototyping, the same part lets teams validate control logic on a Mega board before committing to a custom PCB, since the TQFP footprint carries directly from dev board to production layout with identical firmware and JTAG debugging flow.

What are the key specifications of ATMEGA2560-16AU that engineers should know?
The ATMEGA2560-16AU is an 8-bit AVR RISC microcontroller with 256 KB ISP Flash, 8 KB SRAM, 4 KB EEPROM, 86 GPIO lines, and a 16 MHz maximum clock in a 100-pin TQFP (14x14 mm) package. It integrates six timers, a 10-bit ADC, four USARTs, SPI, TWI, and JTAG, and operates from 4.5V to 5.5V at full speed. According to the Microchip product page, it achieves throughput near 1 MIPS per MHz, making it the standard processor of the Arduino Mega 2560 platform.
What is the operating voltage of ATMEGA2560-16AU?
The ATMEGA2560-16AU operates from 4.5V to 5.5V when running at its full 16 MHz speed. The -16 speed grade requires this 5V-class supply per the Microchip ATmega2560 datasheet. If your system runs at 2.7V to 5.5V, the ATMEGA2560V-8AU variant is the appropriate choice, but its maximum clock is limited to 8 MHz, so designs needing full-speed operation must stay on the 16AU with a regulated 5V rail.
What is the difference between ATMEGA2560-16AU and ATMEGA2560V-8AU?
The difference is speed grade and voltage range: the ATMEGA2560-16AU runs up to 16 MHz at 4.5V-5.5V, while the ATMEGA2560V-8AU runs up to 8 MHz at 1.8V-5.5V. Both are pin-compatible in the 100-TQFP package with identical 256 KB Flash, 8 KB SRAM, and 4 KB EEPROM, as confirmed by comparison data on FindIC and Findchips. Choose the 16AU for maximum throughput on a 5V rail; choose the V-8AU for battery-powered designs that can tolerate half the clock rate.
Is ATMEGA1280-16AU a drop-in replacement for ATMEGA2560-16AU?
Yes, the ATMEGA1280-16AU is pin-to-pin compatible with the ATMEGA2560-16AU in the same 100-TQFP package, so it fits the same PCB footprint. The trade-off is memory: the ATmega1280 offers 128 KB Flash and 8 KB SRAM versus 256 KB Flash on the ATmega2560, with the same peripheral set per the Microchip datasheet. Code compiled for the 2560 runs unmodified on the 1280 only if it fits within 128 KB of Flash; verify your linker output before switching.
What is the best drop-in replacement for ATMEGA2560-16AU?
The best drop-in replacements are same-family Microchip AVR parts in the same 100-TQFP package: ATMEGA1280-16AU (identical peripherals, 128 KB Flash) for designs that fit in less memory, and ATMEGA640-16AU (64 KB Flash) for cost-optimized builds, both verified pin-compatible in Utmel comparison data. The ATMEGA2560V-8AU is also drop-in but halves the maximum clock to 8 MHz. There is currently no verified cross-brand pin-compatible replacement with better specifications; forum consensus (Reddit r/AskElectronics) confirms no STM32/GD32-style equivalent exists for this footprint.
Can ATMEGA2560-16AU be used in an Arduino Mega 2560 board?
Yes, the ATMEGA2560-16AU is the standard processor of the Arduino Mega 2560 and its R3 revisions. Keyestudio and other manufacturers' documentation explicitly state their Mega 2560-compatible boards use the ATMEGA2560-16AU core and are fully compatible with Arduino Mega 2560 REV3 firmware. When replacing the chip on such a board, the replacement must be pre-programmed with the Arduino bootloader (via ICSP) or programmed through an external ISP programmer before it will accept sketches over USB.
How much Flash and SRAM does the ATMEGA2560-16AU have?
The ATMEGA2560-16AU contains 256 KB of in-system programmable Flash, 8 KB of internal SRAM, and 4 KB of EEPROM, according to the Microchip ATmega2560 product page. The Flash includes a separate boot lock section supporting In-Application Programming, which is how the Arduino bootloader self-updates. Of the 256 KB Flash, the first 128 KB is reachable by ordinary program memory instructions; the upper portion is accessed via the RAMPZ register, which the compiler handles automatically.
How many GPIO pins does the ATMEGA2560-16AU have?
The ATMEGA2560-16AU provides 86 general-purpose I/O lines organized as ports A through L (excluding some supply and JTAG pins), according to the Microchip product page. Each I/O line offers configurable internal pull-ups, and many pins carry alternate functions such as timer PWM outputs, USART/SPI/TWI serial links, and ADC inputs. This high pin count is the main reason the Mega 2560 platform supports stacked shields with displays, sensors, and motor drivers simultaneously.
Where to buy ATMEGA2560-16AU and what is the price?
The ATMEGA2560-16AU is available from major distributors including DigiKey, LCSC, and Heisener. As of 2026-09-17, LCSC lists it from about $11.21 per unit in single-piece quantity with hundreds in stock, and Heisener reports roughly 15,312 pieces available. Volume pricing typically steps down through 10, 100, and 1000-piece breaks; XAIPART publishes current tier pricing on this page. Always compare at least two distributors, as stock and pricing for AVR MCUs fluctuate with supply conditions.
Is ATMEGA2560-16AU in stock and what is the lead time?
Yes, the ATMEGA2560-16AU is widely in stock as of 2026-09-17: DigiKey lists it as buy-now with same-day shipping, Heisener shows approximately 15,312 pieces in stock, and LCSC lists several hundred pieces. Lead time for stocked positions is effectively immediate from distributors; broker or allocation channels may quote multi-week lead times. If your BOM needs thousands of units, request a quote with delivery schedule since bulk allocations occasionally lag behind shelf-stock availability.
ATMEGA2560-16AU vs ATMEGA640-16AU - which should I choose?
Choose the ATMEGA2560-16AU when your application needs more than 64 KB of program memory; choose the ATMEGA640-16AU when cost matters and code fits in 64 KB Flash. Both are pin-compatible in the 100-TQFP package with the same core, peripherals, and I/O, as detailed in Utmel's side-by-side comparison. The 640 has smaller Flash (64 KB) but otherwise identical 8 KB SRAM, timers, and USARTs. Designers often lay out the Mega 2560 footprint and populate whichever family member fits the final code size.
When should I choose ATMEGA2560-16AU over ATMEGA328P?
Choose the ATMEGA2560-16AU when your design needs more memory or I/O than the ATmega328P provides: 256 KB versus 32 KB Flash, 8 KB versus 2 KB SRAM, 86 versus 23 I/O lines, and four USARTs versus one. The 328P suits compact, low-pin-count designs at lower cost. For robotics controllers, 3D printer boards, and shield-rich Arduino Mega projects, the 2560 is the appropriate choice, as analyzed in published ATmega2560 vs ATmega328P comparisons; the extra memory directly enables complex sketches and multiple peripherals.
What is the best cross-brand equivalent for ATMEGA2560-16AU?
There is no verified cross-brand pin-compatible equivalent for the ATMEGA2560-16AU. Community discussions (Reddit r/AskElectronics) note that unlike the STM32F103/GD32F303 pairing, no competitor chip offers pin-to-pin compatibility in this 100-TQFP footprint with AVR-compatible operation. Boards like the ShieldBuddy TC275 mimic the Mega 2560 connector layout but use a completely different 32-bit processor and require new firmware. If cross-brand migration is required, plan a board redesign rather than expecting a drop-in swap.
Where can I download the ATMEGA2560-16AU datasheet PDF?
The ATMEGA2560-16AU datasheet PDF can be downloaded from the Microchip product page at microchip.com/en-us/product/ATmega2560, which links the latest full datasheet (the historical Atmel document runs several hundred pages and covers the ATmega640/1280/2560 family). Mirror copies are also hosted on datasheet aggregators such as alldatasheet.com and datasheets.com. Always prefer the Microchip official copy since it carries the latest errata and revision history that third-party mirrors may lack.
Where can I find the ATMEGA2560-16AU pinout?
The complete 100-pin TQFP pinout for the ATMEGA2560-16AU is documented in the ATmega640/1280/2560 family datasheet available on the Microchip product page, in the pin configuration section covering the TQFP package. The pin map assigns ports A through L across the 100 pins along with VCC, GND, AVCC, AREF, RESET, XTAL1/XTAL2, and JTAG pins. The Arduino Mega documentation also provides a board-level pin mapping diagram that translates the MCU pin numbers into Arduino digital/analog labels.
Is the ATMEGA2560-16AU still in production and supported?
Yes, the ATMEGA2560-16AU is an active, in-production product listed on the Microchip ATmega2560 product page and continuously stocked by major distributors as of 2026-09-17. Microchip, which acquired Atmel in 2016, continues to supply the entire AVR ATmega family, and the Arduino ecosystem keeps firmware and toolchain support current. For new designs, the part is a safe choice for long-term availability; still, register a second-source strategy using the pin-compatible ATmega1280/640 family members for supply resilience.
Hey Google, what can replace ATMEGA2560-16AU in an existing Mega 2560 board?
The most direct replacement for an ATMEGA2560-16AU on an existing Mega 2560 board is another ATMEGA2560 in a TQFP package, such as the ATMEGA2560-16AUR (tape-and-reel of the same die). Same-family drop-ins include the ATMEGA1280-16AU and ATMEGA640-16AU if your code fits in 128 KB or 64 KB Flash respectively, per Utmel cross-comparison data. Any replacement must be flashed with the Arduino bootloader via ICSP before use. No cross-brand pin-compatible chip exists for this socket.

Engineering reference data for ATMEGA2560-16AU β€” comparison, design guidance, and compliance information.

Selection Guide

Choose the ATMEGA2560-16AU when you need the largest program memory (256 KB) and full 16 MHz speed in the standard Mega 2560 100-TQFP footprint, especially for Arduino Mega-compatible products, robotics controllers, and shield-rich industrial designs on a 5V rail. Choose the ATMEGA1280-16AU if your verified code size fits under 128 KB and you want an identical pinout with a lower-cost die. Choose the ATMEGA640-16AU for further cost reduction when 64 KB Flash suffices - all three swap on the same PCB. Choose the ATMEGA2560V-8AU only when the supply rail is below 4.5V or battery operation demands the 1.8V-5.5V range, accepting the halved 8 MHz clock. No cross-brand pin-compatible alternative exists; migrating to 32-bit platforms requires a board redesign and new firmware.

Comparison with Alternatives

Parameter This Product ATMEGA1280-16AU ATMEGA640-16AU ATMEGA2560V-8AU
Package 100-TQFP (14x14 mm) 100-TQFP (14x14 mm) - same 100-TQFP (14x14 mm) - same 100-TQFP (14x14 mm) - same
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Flash Memory 256 KB 128 KB 64 KB 256 KB
SRAM 8 KB 8 KB 8 KB 8 KB
EEPROM 4 KB 4 KB 4 KB 4 KB
Max Clock Frequency 16 MHz 16 MHz 16 MHz 8 MHz
GPIO Lines 86 86 86 86
Supply Voltage 4.5 V to 5.5 V (at 16 MHz) 4.5 V to 5.5 V (at 16 MHz) 4.5 V to 5.5 V (at 16 MHz) 1.8 V to 5.5 V (at 8 MHz)

Key Differentiators

  • Largest Flash in the pin-compatible family (vs ATMEGA1280-16AU)
  • Full 16 MHz throughput on a 5V rail (vs ATMEGA2560V-8AU)
  • Memory-optimized cost path exists without redesign (vs ATMEGA640-16AU)

Design Notes

Provide a 100 nF ceramic decoupling capacitor at every VCC/GND pin pair of the 100-TQFP package - there are multiple power pin pairs distributed around the 14x14 mm body, and missing even one degrades high-speed output edge quality. Place capacitors within 2 mm of the pins on the bottom layer with short vias to the ground plane. The exposed perimeter also carries AVCC and AREF: isolate the analog supply with an RC filter (ferrite bead plus 100 nF) from the digital 5V rail to preserve ADC accuracy on the 16 analog channels.

The -16AU speed grade requires a regulated 4.5V-5.5V supply; do not power it from an unregulated or 3.3V rail. Estimated: at 16 MHz with typical peripheral loading, supply current is in the tens of milliamps range - size the 5V regulator for the MCU plus all loads driven by the 86 GPIO lines, which can dominate total current. If the system rail is 3.3V, use the ATMEGA2560V-8AU instead (1.8V-5.5V, 8 MHz max) rather than level-shifting or overclocking the 16AU out of specification.

Do not exceed 16 MHz on the -16 grade and observe the documented frequency-versus-voltage operating envelope from the Microchip datasheet. On Mega 2560-compatible board repairs, remember a replacement chip ships blank: flash the Arduino bootloader via the ICSP header before expecting USB sketch upload. Also reserve the four JTAG pins (TCK/TMS/TDO/TDI) appropriately - JTAG is enabled by default and those pins are unavailable as GPIO unless the JTAGEN fuse is cleared, a frequent source of 'missing I/O pins' confusion on this device.

Compliance Information

RoHS
Unknown
REACH
Unknown
AEC-Q100
Not Applicable
Lead Free
Unknown
Halogen Free
Unknown
Conflict Minerals
Unknown

Compliance status not stated in the provided web data; verify RoHS/REACH status on the Microchip product page or distributor environmental data before final sourcing.

Data verified on: 2026-09-17 β€” data verified and curated by XAIPART's component engineering team

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Related Components & Terms

Microchip Technology Atmel ATMEGA2560-16AU ATmega2560 ATMEGA1280-16AU ATMEGA640-16AU ATMEGA2560V-8AU ATMEGA16U2-AU AVR 8-bit RISC microcontroller MCU ISP Flash EEPROM TQFP-100 Arduino Mega 2560 JTAG USART SPI TWI (I2C) 10-bit ADC ICSP 1 MIPS per MHz
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